Organic Chemistry Portal



Enantioselective Copper-Catalyzed Methylboration of Alkenes

Bin Chen, Peng Cao, Yang Liao, Min Wang and Jian Liao*

*Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, People's Republic of China and University of Chinese Academy of Sciences, Beijing 10049, People's Republic of China, Email:

B. Chen, P. Cao, Y. Liao, M. Wang, J. Liao, Org. Lett., 2018, 20, 1346-1349.

DOI: 10.1021/acs.orglett.7b03860

see article for more reactions


An enantioselective Cu-catalyzed borylative cross-coupling reaction of alkenes, bis(pinacolato)diboron, and methyl iodide provides the desired methylboration products with excellent diastereoselectivities and enantioselectivities.

see article for more examples

Key Words

boration, benzylation, multicomponent reactions

ID: J54-Y2018