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Lewis Base/Copper Cooperatively Catalyzed Asymmetric α-Amination of Esters with Diaziridinone

Jin Song , Zi-Jing Zhang, Shu-Sen Chen, Tao Fan and Liu-Zhu Gong*

*Department of Chemistry, and Center for Excellence in Molecular Synthesis of CAS, University of Science and Technology of China, Hefei 230026, China, Email:

J. Song, J.-Z. Zhang, S.-S. Chen, T. Fan, L.-Z. Gong, J. Am. Chem. Soc., 2018, 140, 3177-3180.

DOI: 10.1021/jacs.7b12628 (free Supporting Information)

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Chiral lewis base/copper(I) cooperative catalysis enables an enantioselective α-amination of esters with N,N-di-t-butyldiaziridinone to provide hydantoins in good yields with excellent enantioselectivities.

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proposed mechanism

Key Words


ID: J48-Y2018