T3P® - A Benign Desulfurating Reagent in the Synthesis of Isothiocyanates
Łukasz Janczewski, Anna Gajda, Sebastian Frankowski, Tomasz M. Goszczyński, Tadeusz Gajda*
*Institute of Organic Chemistry, Faculty of Chemistry, Lodz University of Technology, 116 Stefan Żeromski St., 90-924 Lodz, Poland, Email: tadeusz.gajdap.lodz.pl
Ł Janczewski, A. Gajda, S. Frankowski, T. M. Goszczyński, T. Gajda, Synthesis, 2018, 50, 1141-1151.
DOI: 10.1055/s-0036-1591842 (free Supporting Information)
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A two-step, one-pot reaction of primary amines or their salts with carbon disulfide, followed by reaction of the intermediate dithiocarbamates with T3P provides isothiocyanates in good yields. T3P® (propane phosphonic acid anhydride) acts as an efficient desulfurating agent.
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isothiocyanates, desulfuration, propane phosphonic acid anhydride (T3P®), dithiocarbamates, amino acids, amines