Organic Chemistry Portal



T3P - A Benign Desulfurating Reagent in the Synthesis of Isothiocyanates

Łukasz Janczewski, Anna Gajda, Sebastian Frankowski, Tomasz M. Goszczyński, Tadeusz Gajda*

*Institute of Organic Chemistry, Faculty of Chemistry, Lodz University of Technology, 116 Stefan Żeromski St., 90-924 Lodz, Poland, Email:

Ł Janczewski, A. Gajda, S. Frankowski, T. M. Goszczyński, T. Gajda, Synthesis, 2018, 50, 1141-1151.

DOI: 10.1055/s-0036-1591842

see article for more reactions


A two-step, one-pot reaction of primary amines or their salts with carbon disulfide, followed by reaction of the intermediate dithiocarbamates with T3P provides isothiocyanates in good yields. T3P (propane phosphonic acid anhydride) acts as an efficient desulfurating agent.

see article for more examples

Key Words

isothiocyanates, desulfuration, propane phosphonic acid anhydride (T3P), dithiocarbamates, amino acids, amines

ID: J66-Y2018