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Iridium(I)-Catalyzed Alkylation Reactions To Form α-Alkylated Ketones

Sertaç Genç, Salih Günnaz, Bekir Çetinkaya, Süleyman Gülcemal and Derya Gülcemal*

*Chemistry Department, Ege University, Bornova, 35100 Izmir, Turkey, Email: derya.gulcemalege.edu.tr

S. Genç, S. Günnaz, B. Çetinkaya, S. Gülcemal, D. Gülcemal, J. Org. Chem., 2018, 83, 2875-2881.

DOI: 10.1021/acs.joc.8b00043 (free Supporting Information)


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Abstract

[IrCl(COD)(NHC)] complexes catalyze reactions of primary alcohols with secondary alcohols or ketones to provide various α-alkylated ketones in high yields. The borrowing hydrogen reactions work in the presence of 0.05-0.5% iridium(I) and a catalytic amount of KOH (5-10 mol %) as the base under air atmosphere and within very short reaction times.

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Key Words

alkylation


ID: J42-Y2018