Highly Diastereoselective Synthesis of Trifluoromethyl Indolines by Interceptive Benzylic Decarboxylative Cycloaddition of Nonvinyl, Trifluoromethyl Benzoxazinanones with Sulfur Ylides under Palladium Catalysis
Nagender Punna, Pulakesh Das, Véronique Gouverneur and Norio Shibata*
*Department of Nanopharmaceutical Sciences & Department of
Life Science and Applied Chemistry, Nagoya Institute of Technology, Gokiso,
Showa-ku, Nagoya 466-8555, Japan, Email: nozshiba
nitech.ac.jp
N. Punna, P. Das, V. Gouverneur, N. Shibata, Org. Lett., 2018, 20, 1526-1529.
DOI: 10.1021/acs.orglett.8b00237
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Abstract
A Pd-catalyzed interceptive decarboxylative benzylic cycloaddition (IDBC) of nonvinyl, trifluoromethyl benzoxazinanones with sulfur ylides enables a highly diastereoselective synthesis of trifluoromethyl-substituted indolines via palladium-π-benzyl zwitterionic intermediates.
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Key Words
ID: J54-Y2018
