Controlled Single and Double Iodofluorination of Alkynes with DIH- and HF-Based Reagents
Lukas Pfeifer and Véronique Gouverneur*
*Chemistry Research Laboratory, University of Oxford,
Mansfield Road, Oxford, OX1 3TA, U.K., Email: veronique.gouverneur
chem.ox.ac.uk
L. Pfeifer, V. Gouverneur, Org. Lett., 2018, 20, 1576-1579.
DOI: 10.1021/acs.orglett.8b00321
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Abstract
The use of 1,3-diiodo-5,5,-dimethylhydantoin and HF-based reagents enables a regio- and stereoselective iodofluorination of internal and terminal alkynes. A facile method for a controlled regioselective double iodofluorination of terminal alkynes is also presented.
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Key Words
iodination, fluorination, 1,3-diiodo-5,5,-dimethylhydantoin, multicomponent reactions
ID: J54-Y2018
