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Chemoselective Synthesis of N-Arylenaminones and 3-Aroylquinolines by Synergistic Control of Temperature and Amount of Catalyst

Pan Zhou, Biao Hu, Kairui Rao, Lingdan Li, Jiao Yang, Chuanzhu Gao, Fengping Wang, Fuchao Yu*

*Research Center of Food Engineering, Kunming University of Science and Technology, Kunming, 650504, P. R. of China, Email:

P. Zhou, B. Hu, K. Rao, L. Li, J. Yang, C. Gao, F. Wang, F. Yu, Synlett, 2018, 29, 519-524.

DOI: 10.1055/s-0036-1590950

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Synergistic control of the temperature and amount of catalyst enables a divergent synthesis of N-arylenaminones and 3-aroylquinolines from 2-aminoaryl ketones and N,N-dimethylenaminones in the presence of 4-toluenesulfonic acid. The protocols offers mild conditions, good functional-group tolerance, operational simplicity, and excellent yields.

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Key Words

divergent synthesis, arylenaminones, aroylquinolines, quinolines, dimethylenaminones

ID: J60-Y2018