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Pd(II)-Catalyzed Denitrogenative and Desulfinative Addition of Arylsulfonyl Hydrazides with Nitriles

Mengting Meng, Liangfeng Yang, Kai Cheng* and Chenze Qi

*Zhejiang Key Laboratory of Alternative Technologies for Fine Chemicals Process, Shaoxing University, Shaoxing 312000, People’s Republic of China, Email: chengkaiusx.edu.cn

M. Meng, L. Yang, K. Cheng, C. Qi, J. Org. Chem., 2018, 83, 3275-3284.

DOI: 10.1021/acs.joc.8b00211 (free Supporting Information)


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Abstract

A Pd(II)-catalyzed denitrogenative and desulfinative addition of arylsulfonyl hydrazides to nitriles provides aryl ketones under mild conditions. The reaction tolerates many common functional groups, and works well in the presence of electron-donating and electron-withdrawing substituents.


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Key Words

aryl ketones


ID: J42-Y2018