Facile Synthesis of β-Keto Sulfones Employing Fenton's Reagent in DMSO
Petrakis N. Chalikidi, Maxim G. Uchuskin, Igor V. Trushkov, Vladimir T. Abaev*, Olga V. Serdyuk*
*K. L. Khetagurov North Ossetian State University, Vatutina
St. 46, 362025 Vladikavkaz, Russian Federation; University of Erlangen-Nuremberg,
Henkestrasse 42, 91054 Erlangen, Germany, Email: hampazero
mail.ru,
oserdukemail.ru
P. N. Chalikidi, M. G. Uchuskin, I. V. Trushkov, V. T. Abaev, O. V. Serdyuk, Synlett, 2018, 29, 571-575.
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Abstract
A reaction of xanthates, DMSO, and Fenton's reagent proceeds under very mild conditions to provide various β-keto sulfones in high yields.
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A dropwise addition of hydrogen peroxide is needed, as an addition in one portion can result in vigorous runaway with excess heating.
Vladimir T. Abaev, January 5, 2019
Key Words
β-keto sulfones, sulfones, xanthates, dimethyl sulfoxide, Fenton's reagent, hydrogen peroxide, radical reaction
ID: J60-Y2018
