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Nickel-Catalyzed Addition of Arylboronic Acids to Alkyl Nitriles for Synthesis of Aryl Ketones in Fluorinated Solvent

Dong-Huai Tu, Yang Li, Bo Zhao, Yu-Jie Gu, Bo Wang, Ju-You Lu, Jian Lu*

*Xi'an Modern Chemistry Research Institute, Xi’an 710065, P. R. of China, Email:

D.-H. Tu, Y. Li, B. Zhao, Y.-J. Gu, B. Wang, J.-Y. Lu, J. Lu, Synlett, 2018, 29, 593-596.

DOI: 10.1055/s-0036-1589137 (free Supporting Information)

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A mild and efficient nickel-catalyzed addition of a broad range of arylboronic acids to alkyl nitriles in a fluorinated solvent provides various aryl ketones in very good yields.

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Key Words

nickel catalysis, arylboronic acids, alkyl nitriles, aryl ketones, fluorinated solvents

ID: J60-Y2018