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Syntheses of 2-Aroyl Benzofurans through Cascade Annulation on Arynes

Pashikanti Gouthami, Lahu N. Chavan, Rambabu Chegondi and Srivari Chandrasekhar*

*Natural Products Chemistry Division, Organic & Biomolecular Chemistry Division, CSIR-Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad 500007, India, Email:

P. Gouthami, L. N. Chavan, R. Chegondi, S. Chadrasekhar, J. Org. Chem., 2018, 83, 3325-3332.

DOI: 10.1021/acs.joc.8b00360 (free Supporting Information)

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A cascade reaction composed of a [2+2] annulation of DMF with an aryne followed by a trapping with a sulfur ylide enables the synthesis of a broad range of 2-aroyl benzofurans with high functional-group tolerance.

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ID: J42-Y2018