Synthesis of 4-Aryl Isoquinolinedione Derivatives by a Palladium-Catalyzed Coupling Reaction of Aryl Halides with Isoquinoline-1,3(2H,4H)-diones
Yuanyong Yang, Yingxian Li, Cheng Cheng, Guo Yang, Jiquan Zhang, Yi Zhang, Yonglong Zhao, Lin Zhang, Chun Li* and Lei Tang*
*State Key Laboratory of Functions and Applications of
Medicinal Plants, Guizhou Medical University, Guiyang 550014, China, Email:
scuchunli
163.com, 2317972657qq.com
Y. Yang, Y. Li, C. Cheng, G. Yang, J. Zhang, Y. Zhang, Y. Zhao, L. Zhang, C. Li, L. Tang, J. Org. Chem., 2018, 83, 3348-3353.
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Abstract
A palladium-catalyzed cross-coupling reaction of aryl halides with isoquinoline-1,3(2H,4H)-diones enables the synthesis of 4-aryl isoquinoline-1,3(2H,4H)-diones. The products could be conveniently transformed to 4-aryl tetrahydroisoquinolines.
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Key Words
ID: J42-Y2018
