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[3 + 3] Cycloaddition of Azides with in Situ Formed Azaoxyallyl Cations To Synthesize 1,2,3,4-Tetrazines

Xiaoying Xu, Kaifan Zhang, Panpan Li, Hequan Yao* and Aijun Lin*

*State Key Laboratory of Natural Medicines (SKLNM) and Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, P. R. China, Email:,

X. Xu, K. Zhang, P. Li, H. Yao, A. Lin, Org. Lett., 2018, 20, 1781-1784.

DOI: 10.1021/acs.orglett.8b00280

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A formal [3 + 3] cycloaddition reaction between azides and in situ formed azaoxyallyl cations provides 1,2,3,4-tetrazines in good yields under mild conditions.

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Key Words

1,2,3,4-tetrazines, N-heterocycles

ID: J54-Y2018