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Ni-Catalyzed Formal Carbonyl-Ene Reaction of Terminal Alkenes via Carbon Dioxide Insertion

Yasuyuki Mori, Chieko Shigeno, Ying Luo, Bun Chan, Gen Onodera, Masanari Kimura *

*Graduate School of Engineering, Nagasaki University, Bunkyo-machi 1-14, Nagasaki 852-8521, Japan, Email:

Y. Mori, C. Shigeno, Y. Luo, B. Chan, G. Onodera, M. Kimura, Synlett, 2018, 29, 742-746.

DOI: 10.1055/s-0036-1591845 (free Supporting Information)

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Nickel catalyzes a multicomponent coupling reaction of terminal alkenes, carbon dioxide, and organoaluminum reagents to provide homoallylic alcohols in good yields with excellent regio- and stereoselectivities.

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Key Words

nickel catalyst, carbon dioxide, carbonyl-ene, ketone, homoallylic alcohols, 1,2-addition, organoaluminum, multicomponent reactions

ID: J60-Y2018