Synthesis of Alkyl Indium Reagents by Using Unactivated Alkyl Chlorides and Their Applications in Palladium-Catalyzed Cross-Coupling Reactions with Aryl Halides
Bing-Zhi Chen, Man-Ling Zhi, Chuang-Xin Wang, Xue-Qiang Chu, Zhi-Liang Shen* and Teck-Peng Loh*
*Nanjing Tech University, Nanjing 211816, China; Nanyang Technological University, Singapore 637371, Singapore, Email: ias_zlshennjtech.edu.cn, teckpengntu.edu.sg
B.-Z. Chen, M.-L. Zhi, C.-X. Wang, X.-Q. Chu, Z.-L. Shen, T.-P. Loh, Org. Lett., 2018, 20, 1902-1905.
DOI: 10.1021/acs.orglett.8b00441 (free Supporting Information)
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An efficient reaction of unactivated and cheap alkyl chlorides in the presence of indium and LiI provides alkyl indium species, that effectively underwent palladium-catalyzed cross-coupling reactions with aryl halides with wide functional group tolerance.
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