A Highly Efficient CuCl₂-Catalyzed C-S Coupling of Aryl Iodides with Tetraalkylthiuram Disulfides: Synthesis of Aryl Dithiocarbamates

Qiang Cao, Han-Ying Peng, Yu Cheng, Zhi-Bing Dong*

*School of Chemistry and Environmental Engineering, Wuhan Institute of Technology, Wuhan 430205, P. R. of China, Email: dzb04982wit.edu.cn

Q. Cao, H.-Y. Peng, Y. Cheng, Z.-B. Dong, Synthesis, 2018, 50, 1527-1534.

DOI: 10.1055/s-0036-1589166

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Abstract

With only 1 mol% of CuCl₂ as catalyst, zinc powder as reductant, and K₂CO₃ as base, a highly efficient C-S cross-coupling reaction of aryl iodides with tetraalkylthiuram disulfides provides dithiocarbamates in very good yields. This protocol has a broad substrate scope and uses cheap and readily available starting materials.

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An Efficient Copper-Catalyzed C(sp²)-S Formation Starting from Aryl Iodides and Tetramethylthiuram Monosulfide (TMTM)

Y.-X. Wu, K. Peng, J.-H. Li, Z.-B. Dong, Synthesis, 2020, 52, 3001-3006.

Copper-Catalyzed C(sp²)-S Coupling Reactions for the Synthesis of Aryl Dithiocarbamates with Thiuram Disulfide Reagents

Z.-B. Dong, X. Liu, C. Bolm, Org. Lett., 2017, 19, 5916-5919.

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Key Words

dithiocarbamates

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ID: J66-Y2018