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Design and Application of Hybrid Phosphorus Ligands for Enantioselective Rh-Catalyzed Anti-Markovnikov Hydroformylation of Unfunctionalized 1,1-Disubstituted Alkenes

Cai You, Shuailong Li, Xiuxiu Li, Jialing Lan, Yuhong Yang, Lung Wa Chung, Hui Lv* and Xumu Zhang*

*Wuhan University, Wuhan, Hubei 430072; Southern University of Science and Technology, Shenzhen, Guangdong 518055, China, Email: huilvwhu.edu.cn, zhangxmsustc.edu.cn

C. You, S. Li, X. Li, J. Lan, Y. Yang, L. W. Chung, H. Lv, X. Zhang, J. Am. Chem. Soc., 2018, 140, 4977-4981.

DOI: 10.1021/jacs.8b00275 (free Supporting Information)


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Abstract

Hybrid phosphorus ligands enable a Rh-catalyzed enantioselective anti-Markovnikov hydroformylation of unfunctionalized 1,1-disubstituted alkenes to provide linear aldehydes with β-chirality in high yields and enantioselectivities under mild conditions. In a large-scale synthesis, a very low catalyst loading (0.05 mol %) furnished the desired product in good yield and undiminished selectivity.

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Key Words

carbonyl compounds


ID: J48-Y2018