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Iron-Catalyzed Highly Enantioselective Hydrosilylation of Unactivated Terminal Alkenes

Biao Cheng, Wenbo Liu and Zhan Lu*

*Department of Chemistry, Zhejiang University, Hangzhou 310058, China, Email: luzhanzju.edu.cn

B. Cheng, W. Liu, Z. Lu, J. Am. Chem. Soc., 2018, 140, 5014-5017.

DOI: 10.1021/jacs.8b01638 (free Supporting Information)



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Abstract

An iron-catalyzed highly Markovnikov-type selective and enantioselective hydrosilylation of terminal aliphatic alkenes with good functional group tolerance provides valuable chiral organosilanes with high ees. Chiral aliphatic alkan-2-ols could be efficiently synthesized via further derivatization of chiral organosilanes without any racemization.

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Key Words

alkylsilanes


ID: J48-Y2018