Organic Chemistry Portal



Transition-Metal-Free C-P Bond Formation via Decarboxylative Phosphorylation of Cinnamic Acids with P(O)H Compounds

Lixin Liu, Dan Zhou, Jianyu Dong*, Yongbo Zhou*, Shuang-Feng Yin and Li-Biao Han

*State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China, Email:,

L. Liu, D. Zhou, J. Dong, Y. Zhou, S.-F. Yin, L.-B. Han, J. Org. Chem., 2018, 83, 4190-4196.

DOI: 10.1021/acs.joc.8b00187 (free Supporting Information)

see article for more reactions


A radical-promoted decarboxylation enables a transition-metal-free phosphorylation of cinnamic acids with P(O)H compounds under mild conditions. This method provides simple, efficient, and versatile access to a broad range of valuable (E)-alkenylphosphine oxides in good yields.

see article for more examples

Key Words

phosphine oxides, tert-butyl peroxybenzoate (TBPB)

ID: J42-Y2018