One-Step Synthesis of Aliphatic Potassium Acyltrifluoroborates (KATs) from Organocuprates
Sizhou M. Liu, Dino Wu and Jeffrey W. Bode*
*Laboratorium für Organische Chemie, Department of Chemistry and Applied Biosciences, ETH Zürich, 8093 Zürich, Switzerland, Email: bodeorg.chem.ethz.ch
S. M. Liu, D. Wu, J. W. Bode, Org. Lett., 2018, 20, 2378-2381.
DOI: 10.1021/acs.orglett.8b00720 (free Supporting Information)
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In a one-step synthesis of aliphatic potassium acyltrifluoroborates (KATs) from organocuprates, organolithium and organomagnesium reagents were readily transmetalated onto Cu(I) and coupled with a KAT-forming reagent. The protocol is suitable for primary, secondary and tertiary alkyl substrates.
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