Visible-Light-Driven Alkyne Hydro-/Carbocarboxylation Using CO₂ via Iridium/Cobalt Dual Catalysis for Divergent Heterocycle Synthesis

Jing Hou, Aloysius Ee, Wei Feng, Jin-Hui Xu, Yu Zhao* and Jie Wu*

*Department of Chemistry, National University of Singapore, 3 Science Drive 3, Republic of Singapore 117543, Email: zhaoyunus.edu.sg, chmjienus.edu.sg

J. Hou, A. Ee, W. Feng, J.-H. Xu, Y. Zhao, J. Wu, J. Am. Chem. Soc., 2018, 140, 5257-5263.

DOI: 10.1021/jacs.8b01561

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Abstract

Visible-light-driven hydrocarboxylations as well as carbocarboxylations of alkynes using CO₂ via an iridium/cobalt dual catalysis provide access to various pharmaceutically important heterocycles in a one-pot procedure from readily available alkynes. Coumarins, 2-quinolones, and 2-benzoxepinones were directly accessed through a one-pot alkyne hydrocarboxylation/alkene isomerization/cyclization sequence.

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Key Words

coumarins, 2-quinolones, photochemistry

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ID: J48-Y2018