Molecular Iodine Catalysed Benzylic sp3 C-H Bond Amination for the Synthesis of 2-Arylquinazolines from 2-Aminobenzaldehydes, 2-Aminobenzophenones and 2-Aminobenzyl Alcohols
Dewal S. Deshmukh, Bhalchandra M. Bhanage*
*Department of Chemistry, Institute of Chemical Technology, Matunga, Mumbai-400019, India, Email: bm.bhanageictmumbai.edu.in
D. S. Deshmukh, B. M. Bhanage, Synlett, 2018, 29, 979-985.
DOI: 10.1055/s-0037-1609200 (free Supporting Information)
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Molecular iodine catalyses a benzylic sp3 C-H bond amination of 2-aminobenzaldehydes and 2-aminobenzophenones with benzylamines to provide quinazolines in very good yields. The use of oxygen as an oxidant combined with the transition-metal-, additive- and solvent-free conditions makes the methodology green and economical. 2-Aminobenzyl alcohols could also used as starting materials.
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