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Electrosynthesis of Trisubstituted 2-Oxazolines via Dehydrogenative Cyclization of β-Amino Arylketones

Huiqiao Wang, Jinjin Zhang, Jiajing Tan*, Lilan Xin, Yaping Li, Sheng Zhang* and Kun Xu*

*Nanyang Normal University, Nanyang, Henan 473061; Beijing University of Chemical Technology, Beijing 100029, China, Email: tanjjmail.buct.edu.cn, shengzhangnynu.edu.cn, xukunnynu.edu.cn

H. Wang, J. Zhang, J. Tan, L. Xin, Y. Li, S. Zhang, K. Xu, Org. Lett., 2018, 20, 2505-2508.

DOI: 10.1021/acs.orglett.8b00165 (free Supporting Information)


Abstract

An electrochemically intramolecular functionalization of C(sp3)-H bonds with masked oxygen nucleophiles provides diverse trisubstituted 2-oxazolines in good to excellent yields. This electrochemical dehydrogenative approach in the presence of KI as the catalyst and electrolyte features external oxidant-free conditions.


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Key Words

2-oxazolines, electrochemistry


ID: J54-Y2018