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Palladium-Catalyzed Direct C-H Carbonylation of Free Primary Benzylamines: A Synthesis of Benzolactams

Chunhui Zhang, Yongzheng Ding, Yuzhen Gao, Shangda Li* and Gang Li*

*Key Laboratory of Coal to Ethylene Glycol and Its Related Technology, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China, Email:,

C. Zhang, Y. Ding, Y. Gao, S. Li, G. Li, Org. Lett., 2018, 20, 2595-2598.

DOI: 10.1021/acs.orglett.8b00786

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A palladium-catalyzed C-H carbonylation of readily available free primary benzylamines, in which NH2 acts as a chelating group, provides benzolactams under an atmospheric pressure of CO. Application of this new method is exemplified in the concise syntheses of two bioactive molecules.

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ID: J54-Y2018