Organic Chemistry Portal

Abstracts

Search:

Palladium-Catalyzed Direct C-H Carbonylation of Free Primary Benzylamines: A Synthesis of Benzolactams

Chunhui Zhang, Yongzheng Ding, Yuzhen Gao, Shangda Li* and Gang Li*

*Key Laboratory of Coal to Ethylene Glycol and Its Related Technology, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China, Email: sdlifjirsm.ac.cn, ganglifjirsm.ac.cn

C. Zhang, Y. Ding, Y. Gao, S. Li, G. Li, Org. Lett., 2018, 20, 2595-2598.

DOI: 10.1021/acs.orglett.8b00786 (free Supporting Information)


see article for more reactions

Abstract

A palladium-catalyzed C-H carbonylation of readily available free primary benzylamines, in which NH2 acts as a chelating group, provides benzolactams under an atmospheric pressure of CO. Application of this new method is exemplified in the concise syntheses of two bioactive molecules.

see article for more examples



Key Words

Isoindolinones


ID: J54-Y2018