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Copper-Catalyzed Synthesis of Polysubstituted Pyrroles through [3+1+1] Cycloaddition Reaction of Nitrones and Isocyanides

Zhuang Tian, Jiaojiao Xu, Bingxin Liu, Qitao Tan* and Bin Xu*

*Department of Chemistry, Innovative Drug Research Center, School of Materials Science and Engineering, Shanghai University, Shanghai 200444, China, Email: xubinshu.edu.cn, qttanshu.edu.cn

Z. Tian, J. Xu, B. Liu, Q. Tan, B. Xu, Org. Lett., 2018, 20, 2603-2606.

DOI: 10.1021/acs.orglett.8b00798 (free Supporting Information)


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Abstract

An efficient, copper-catalyzed [3+1+1] cycloaddition reaction of nitrones and α-acidic isocyanides enables the synthesis of pharmacologically interesting polysubstituted pyrroles. The reaction features wide substrate scope, good functional group tolerance, and operational simplicity.

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Key Words

pyrroles


ID: J54-Y2018