Organic Chemistry Portal



Copper-Catalyzed Synthesis of Polysubstituted Pyrroles through [3+1+1] Cycloaddition Reaction of Nitrones and Isocyanides

Zhuang Tian, Jiaojiao Xu, Bingxin Liu, Qitao Tan* and Bin Xu*

*Department of Chemistry, Innovative Drug Research Center, School of Materials Science and Engineering, Shanghai University, Shanghai 200444, China, Email:,

Z. Tian, J. Xu, B. Liu, Q. Tan, B. Xu, Org. Lett., 2018, 20, 2603-2606.

DOI: 10.1021/acs.orglett.8b00798 (free Supporting Information)

see article for more reactions


An efficient, copper-catalyzed [3+1+1] cycloaddition reaction of nitrones and α-acidic isocyanides enables the synthesis of pharmacologically interesting polysubstituted pyrroles. The reaction features wide substrate scope, good functional group tolerance, and operational simplicity.

see article for more examples

Key Words


ID: J54-Y2018