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Cu-Catalyzed Aerobic Oxidative Sulfuration/Annulation Approach to Thiazoles via Multiple Csp3-H Bond Cleavage

Xiaoyang Wang, Xu Qiu, Jialiang Wei, Jianzhong Liu, Song Song, Wen Wang* and Ning Jiao*

*Peking University, Xue Yuan Road 38, Beijing 100191; Chinese Academy of Sciences, Shanghai 200032, China, Email: jiaoningpku.edu.cn, wangwenmmbjmu.edu.cn

X. Wang, X. Qiu, J. Wei, J. Liu, S. Song, W. Wang, N. Jiao, Org. Lett., 2018, 20, 2632-2636.

DOI: 10.1021/acs.orglett.8b00840 (free Supporting Information)


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Abstract

Practical Cu-catalyzed oxidative, multiple Csp3-H bond cleavage processes achieve a synthesis of thiazoles from simple aldehydes, amines, and element sulfur in the presence of molecular oxygen as a green oxidant.

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Key Words

thiazoles, oxygen, multicomponent reactions


ID: J54-Y2018