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Synthesis of Symmetric and Unsymmetric Secondary Amines from the Ligand-Promoted Ruthenium-Catalyzed Deaminative Coupling Reaction of Primary Amines

Pandula T. Kirinde Arachchige, Hanbin Lee and Chae S. Yi*

*Department of Chemistry, Marquette University, Milwaukee, Wisconsin 53201-1881, United States, Email: chae.yimarquette.edu

P. T. K. Arachchige, H. Lee, C. S. Yi, J. Org. Chem., 2018, 83, 4932-4947.

DOI: 10.1021/acs.joc.8b00649 (free Supporting Information)


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Abstract

A catalytic system generated in situ from a tetranuclear Ru-H complex with a catechol ligand enables a direct deaminative coupling of two primary amines to form secondary amines. The analogous coupling of aniline with primary amines formed aryl-substituted secondary amines.

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Key Words

amines, benzyl amines, aryl amines


ID: J42-Y2018