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Au-Catalyzed Intermolecular [2+2] Cycloadditions between Chloroalkynes and Unactivated Alkenes

Yu-Bin Bai, Zaigang Luo, Yuguang Wang, Jin-Ming Gao* and Liming Zhang*

*College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, China; University of California, Santa Barbara, California 93106, United States, Email: jinminggaonwafu.edu.cn, zhangchem.ucsb.edu

Y.-B. Bai, Z. Luo, Y. Wang, J.-M. Gao, L. Zhang, J. Am. Chem. Soc., 2018, 140, 5860-5865.

DOI: 10.1021/jacs.8b01813 (free Supporting Information)


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Abstract

Gold catalysis enables an efficient intermolecular [2+2] cycloaddition between two different types of chloroalkynes and unactivated alkenes. Monosubstituted unactivated alkenes can be converted with excellent regioselectivities. With 1,2-disubstituted unactivated alkenes, the reaction is largely stereospecific.

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Key Words

cyclobutenes


ID: J48-Y2018