Organic Chemistry Portal



Copper-Catalyzed Oxygenation Approach to Oxazoles from Amines, Alkynes, and Molecular Oxygen

Jun Pan, Xinyao Li, Xu Qiu, Xiao Luo and Ning Jiao*

*State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Road 38, Beijing 100191, China, Email:

J. Pan, X. Li, X. Qiu, X. Luo, N. Jiao, Org. Lett., 2018, 20, 2762-2765.

DOI: 10.1021/acs.orglett.8b00992

see article for more reactions


An efficient copper-catalyzed aerobic oxidative dehydrogenative annulation of amines, alkynes, and O2 provides trisubstituted oxazoles via dioxygen activation and oxidative C-H bond functionalization.

see article for more examples

Key Words

oxazoles, mutlicomponent reactions, oxygen, NIS

ID: J54-Y2018