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Visible Light Promotes Decyanation Esterification Reaction of β-Ketonitriles with Dioxygen and Alcohols to α-Ketoesters

Chen Xu, Nan-Nan Zhang, Xiao-ji Li, Yan-qin Ge, Pin-hui Diao, Cheng Guo*

*College of Chemistry and molecular engineering, Nanjing Tech University, 30 Puzhu South Road, Jiangsu, Nanjing, 211816, P. R. of China, Email:

C. Xu, N.-N. Zhang, X.-j. Li, Y.-q. Ge, P.-h. Diao, C. Guo, Synlett, 2018, 29, 1065-1070.

DOI: 10.1055/s-0036-1591943

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Visible light promotes a green and mild conversion of β-ketonitriles into α-ketoesters under catalyst-free conditions via singlet oxygen generation, oxidative C-H bond functionalization, and C-C σ-bond cleavage.

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Key Words

visible light, α-keto esters, β-ketonitriles, oxygen, metal-free

ID: J60-Y2018