Organic Chemistry Portal



Copper-Catalyzed Synthesis of Multisubstituted Indoles through Tandem Ullmann-Type C-N Formation and Cross-dehydrogenative Coupling Reactions

Yue Li, Jinsong Peng* , Xin Chen, Baichuan Mo, Xue Li, Peng Sun and Chunxia Chen*

*Department of Chemistry and Chemical Engineering, College of Science, Northeast Forestry University, Harbin 150040, P. R. China, Email:,

Y. Li, J. Peng, X. Chen, B. Mo, X. Li, P. Sun, C. Chen, J. Org. Chem., 2018, 83, 5288-5294.

DOI: 10.1021/acs.joc.8b00353


A one-pot tandem copper-catalyzed Ullmann-type C-N bond formation/intramolecular cross-dehydrogenative coupling process enables the synthesis of multisubstituted indoles in very good yields from readily available aryl iodides and enamines at 130C in DMSO.

see article for more examples

Key Words


ID: J42-Y2018