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Copper-Catalyzed Synthesis of Multisubstituted Indoles through Tandem Ullmann-Type C-N Formation and Cross-dehydrogenative Coupling Reactions

Yue Li, Jinsong Peng* , Xin Chen, Baichuan Mo, Xue Li, Peng Sun and Chunxia Chen*

*Department of Chemistry and Chemical Engineering, College of Science, Northeast Forestry University, Harbin 150040, P. R. China, Email: jspeng1998163.com, ccx1759163.com

Y. Li, J. Peng, X. Chen, B. Mo, X. Li, P. Sun, C. Chen, J. Org. Chem., 2018, 83, 5288-5294.

DOI: 10.1021/acs.joc.8b00353 (free Supporting Information)


Abstract

A one-pot tandem copper-catalyzed Ullmann-type C-N bond formation/intramolecular cross-dehydrogenative coupling process enables the synthesis of multisubstituted indoles in very good yields from readily available aryl iodides and enamines at 130C in DMSO.

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Key Words

indoles


ID: J42-Y2018