Cross-Coupling of Amides with Alkylboranes via Nickel-Catalyzed C-N Bond Cleavage
Xiangqian Liu, Chien-Chi Hsiao, Lin Guo and Magnus Rueping*
*RWTH Aachen University, Institute of Organic Chemistry, Landoltweg 1, 52074 Aachen, Germany, Email: magnus.ruepingrwth-aachen.de
X. Liu, C.-C. Hsiao, L. Guo, M. Rueping, Org. Lett., 2018, 20, 2976-2979.
DOI: 10.1021/acs.orglett.8b01021 (free Supporting Information)
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In a protocol for a nickel-catalyzed alkylation of amides, alkylboranes can be used as nucleophilic partners under mild reaction conditions. The reaction tolereates various functional groups with respect to both coupling partners.
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