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Cross-Coupling of Amides with Alkylboranes via Nickel-Catalyzed C-N Bond Cleavage

Xiangqian Liu, Chien-Chi Hsiao, Lin Guo and Magnus Rueping*

*RWTH Aachen University, Institute of Organic Chemistry, Landoltweg 1, 52074 Aachen, Germany, Email: magnus.ruepingrwth-aachen.de

X. Liu, C.-C. Hsiao, L. Guo, M. Rueping, Org. Lett., 2018, 20, 2976-2979.

DOI: 10.1021/acs.orglett.8b01021 (free Supporting Information)


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Abstract

In a protocol for a nickel-catalyzed alkylation of amides, alkylboranes can be used as nucleophilic partners under mild reaction conditions. The reaction tolereates various functional groups with respect to both coupling partners.

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Key Words

aryl ketones


ID: J54-Y2018