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Copper-Catalyzed Synthesis of Substituted Quinazolines from Benzonitriles and 2-Ethynylanilines via Carbon-Carbon Bond Cleavage Using Molecular Oxygen

Xu Wang, Dandan He, Yubing Huang, Qihang Fan, Wanqing Wu* and Huanfeng Jiang*

*State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou 510640, China, Email:,

X. Wang, D. He, Y. Huang, Q. Fan, W. Wu, H. Jiang, J. Org. Chem., 2018, 83, 5458-5446.

DOI: 10.1021/acs.joc.8b00378 (free Supporting Information)

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A copper-catalyzed reaction of benzonitriles and 2-ethynylanilines gave substituted quinazolines in the presence of molecular oxygen (O2) as sole oxidant via cleavage of the C-C triple bond and construction of new C-N and C-C bonds.

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Key Words


ID: J42-Y2018