Palladium-Catalyzed Three-Component Tandem Process: One-Pot Assembly of Quinazolines

Kun Hu, Qianqian Zhen, Julin Gong, Tianxing Cheng, Linjun Qi, Yinlin Shao and Jiuxi Chen*

*College of Chemistry & Materials Engineering, Wenzhou University, Wenzhou, Zhejiang 325035, P. R. China, Email: jiuxichenwzu.edu.cn

K. Hu, Q. Zhen, J. Gong, T. Cheng, L. Qi, Y. Shao, J. Chen, Org. Lett., 2018, 20, 3061-3064.

DOI: 10.1021/acs.orglett.8b01070

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Abstract

A palladium-catalyzed, three-component tandem reaction of 2-aminobenzonitriles, aldehydes, and arylboronic acids provides diverse quinazolines in good yields. The reaction tolerates bromo and iodo groups.

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Key Words

quinazolines, multicomponent reactions

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ID: J54-Y2018