Palladium-Catalyzed Enantioselective Relay Heck Arylation of Enelactams: Accessing α,β-Unsaturated δ-Lactams
Qianjia Yuan and Matthew S. Sigman*
*Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, Utah 84112, United States, Email: sigmanchem.utah.edu
Q. Yuan, M. S. Sigman, J. Am. Chem. Soc., 2018, 140, 6527-6530.
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An oxidative relay Heck arylation reaction enables the construction of chiral α,β-unsaturated δ-lactams, widely used as pharmacophores, in high yields and excellent enantioselectivities. This strategy also allows facile access to 7-substituted α,β-unsaturated ε-lactam products and δ-lactams.
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