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Cobalt-Catalyzed Regioselective Olefin Isomerization Under Kinetic Control

Xufang Liu, Wei Zhang, Yujie Wang, Ze-Xin Zhang, Lei Jiao* and Qiang Liu*

*Center of Basic Molecular Science (CBMS), Department of Chemistry, Tsinghua University, Beijing 100084, China, Email: qiang_liumail.tsinghua.edu.cn, leijiaomail.tsinghua.edu.cn

X. Liu, W. Zhang, Y. Wang, Z.-X. Zhang, L. Jiao, Q. Liu, J. Am. Chem. Soc., 2018, 140, 6873-6882.

DOI: 10.1021/jacs.8b01815 (free Supporting Information)


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Abstract

A cobalt-catalyzed regioselective olefin isomerization reaction with fine-tunable NNP-pincer ligand structures features high kinetic control of regioselectivity. This mild catalytic system enables the isomerization of 1,1-disubstituted olefins bearing a wide range of functional groups in excellent yields and regioselectivity.


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Key Words

cyclohexenes, isomerization


ID: J48-Y2018