Mn(OAc)₃-Mediated Hydrotrifluoromethylation of Unactivated Alkenes Using CF₃SO₂Na as the Trifluoromethyl Source

Bin Cui, Hui Sun, Yibo Xu, Lin Li, Lili Duan* and Yue-Ming Li*

*Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin, People's Republic of China, Email: lduannankai.edu.cn, ymlinankai.edu.cn

B. Cui, H. Sun, Y. Xu, L. Li, L. Duan, Y.-M. Li, J. Org. Chem., 2018, 83, 6015-6024.

DOI: 10.1021/acs.joc.8b00633

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Abstract

A single electron oxidation of the commercially available CF₃SO₂Na (Langlois' reagent) using Mn(OAc)₃·2H₂O as the oxidant enables a simple and efficient method for hydrotrifluoromethylation of unactivated alkenes. The reaction proceeds readily under mild conditions and tolerates various functional groups.

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Key Words

trifluoromethylation, manganese compounds

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ID: J42-Y2018