Nickel-Catalyzed Highly Regioselective Hydrocyanation of Terminal Alkynes with Zn(CN)2 Using Water as the Hydrogen Source
Xingjie Zhang, Xin Xie and Yuanhong Liu*
*Shanghai Institute of Organic Chemistry, University of
Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Lu,
Shanghai 200032, People's Republic of China, Email: yhliu
sioc.ac.cn
X. Zhang, X. Xie, Y. Liu, J. Am. Chem. Soc., 2018, 140, 7385-7389.
DOI: 10.1021/jacs.8b02542
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Abstract
An efficient, regioselective, and general nickel-catalyzed hydrocyanation of terminal alkynes with Zn(CN)2 in the presence of water provides functionalized vinyl nitriles with a range of structural diversity under mild reaction conditions. The use of the volatile and hazardous HCN can be avoided.
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Key Words
ID: J48-Y2018
