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Nickel-Catalyzed Highly Regioselective Hydrocyanation of Terminal Alkynes with Zn(CN)2 Using Water as the Hydrogen Source

Xingjie Zhang, Xin Xie and Yuanhong Liu*

*Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, People's Republic of China, Email:

X. Zhang, X. Xie, Y. Liu, J. Am. Chem. Soc., 2018, 140, 7385-7389.

DOI: 10.1021/jacs.8b02542

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An efficient, regioselective, and general nickel-catalyzed hydrocyanation of terminal alkynes with Zn(CN)2 in the presence of water provides functionalized vinyl nitriles with a range of structural diversity under mild reaction conditions. The use of the volatile and hazardous HCN can be avoided.

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Key Words

vinyl nitriles

ID: J48-Y2018