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Decarbonylative Coupling of α-Keto Acids and Ynamides for Synthesis of β-Keto Imides

Renjie Chen, Linwei Zeng, Bo Huang, Yangyong Shen and Sunliang Cui*

*Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, P. R. China, Email:

R. Chen, L. Zeng, B. Hoang, Y. Shen, S. Cui, Org. Lett., 2018, 20, 3377-3380.

DOI: 10.1021/acs.orglett.8b01302

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An efficient decarbonylative coupling of α-keto acids and ynamides with extrusion of CO enables the synthesis of a broad range of β-keto imides under mild reaction conditions.

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One-Pot Reaction of Carboxylic Acids and Ynol Ethers for The Synthesis of β-Keto Esters

L. Zeng, Z. Lai, S. Cui, J. Org. Chem., 2018, 83, 14834-14841.

Key Words

β-keto amides, hydration

ID: J54-Y2018