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Cyclization of Ketones with Nitriles under Base: A General and Economical Synthesis of Pyrimidines

Lebin Su, Kang Sun, Neng Pan, Long Liu, Mengli Sun, Jianyu Dong*, Yongbo Zhou* and Shuang-Feng Yin

*State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China, Email:,

L. Su, K. Sun, N. Pan, L. Liu, M. Sun, J. Dong, Y. Zhou, S.-F. Yin, Org. Lett., 2018, 20, 3399-3402.

DOI: 10.1021/acs.orglett.8b01324

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A copper-catalyzed cyclization of ketones with nitriles enables a facile, general, and economical synthesis of diversely functionalized pyrimidines under basic conditions. The reaction shows broad substrate scope and tolerates many important functional groups.

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Key Words


ID: J54-Y2018