Organic Chemistry Portal

Abstracts

Search:

Cyclization of Ketones with Nitriles under Base: A General and Economical Synthesis of Pyrimidines

Lebin Su, Kang Sun, Neng Pan, Long Liu, Mengli Sun, Jianyu Dong*, Yongbo Zhou* and Shuang-Feng Yin

*State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China, Email: djyustchotmail.com, zhouybhnu.edu.cn

L. Su, K. Sun, N. Pan, L. Liu, M. Sun, J. Dong, Y. Zhou, S.-F. Yin, Org. Lett., 2018, 20, 3399-3402.

DOI: 10.1021/acs.orglett.8b01324


see article for more reactions

Abstract

A copper-catalyzed cyclization of ketones with nitriles enables a facile, general, and economical synthesis of diversely functionalized pyrimidines under basic conditions. The reaction shows broad substrate scope and tolerates many important functional groups.

see article for more examples



Key Words

pyrimidines


ID: J54-Y2018