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An Efficient Oxidation of Sulfides to Sulfones with Urea-Hydrogen Peroxide in the Presence of Phthalic Anhydride in Ethyl Acetate

Marlon Lutz, Marta Wenzler, Igor Likhotvorik*

*Process Research and Development, Regis Technologies, 8210 Austin Ave., Morton Grove, IL 60053, USA, Email:

M. Lutz, M. Wenzler, I. Likthotvorik, Synthesis, 2018, 50, 2231-2234.

DOI: 10.1055/s-0037-1609446


The use of urea-hydrogen peroxide and phthalic anhydride in ethyl acetate enables a metal-free, environmentally benign oxidation of substituted sulfides to their corresponding sulfones without observation of the possible sulfoxide oxidation product.

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Key Words

sulfones, sulfoxides, sulfide oxidation, urea-hydrogen peroxide, UHP, phthalic anhydride

ID: J66-Y2018