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Synthesis of 1,2,3-Triazines Using the Base-Mediated Cyclization of (Z)-2,4-Diazido-2-alkenoates

Hideyuki Sugimura* , Reika Takeuchi, Shiori Ichikawa, Eri Nagayama and Ikuo Sasaki

*Department of Chemistry and Bioscience, Faculty of Science and Technology, Aoyama Gakuin University, 5-10-1, Fuchinobe, Chuo-ku, Sagamihara 252-5258, Japan, Email:

H. Sugimura, R. Takeuichi, S. Ichikawa, E. Nagayama, I. Sasaki, Org. Lett., 2018, 20, 3434-3437.

DOI: 10.1021/acs.orglett.8b01445

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Readily accessible (Z)-4-aryl-2,4-diazido-2-alkenoates can efficiently be converted to 6-aryl-1,2,3-triazine-4-carboxylate esters under mildly basic conditions without the assistance of any transition metals or strong acid.

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Key Words


ID: J54-Y2018