Ligand-Free Iron-Catalyzed Carbon(sp²)-Carbon(sp²) Cross-Coupling of Alkenyllithium with Vinyl Halides

Qiang Liu, Zhi-Yong Wang, Xiao-Shui Peng* and Henry N. C. Wong*

*Department of Chemistry and State Key Laboratory of Synthetic Chemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China, Email: xspengcuhk.edu.hk, hncwongcuhk.edu.hk

Q. Liu, Z.-Y. Wang, X.-S. Peng, H. N. C. Wong, J. Org. Chem., 2018, 83, 6325-6333.

DOI: 10.1021/acs.joc.8b00510

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Abstract

An efficient ligand-free iron-catalyzed cross-coupling reaction involving alkenyllithium reagents and vinyl iodides provides dienes in moderate yields. This reaction offers a mild, inexpensive, and environmentally friendly avenue toward synthesis of diversified diene derivatives.

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Key Words

Dienes

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ID: J42-Y2018