Asymmetric [4 + 2]-Cycloaddition of Copper-Allenylidenes with Hexahydro-1,3,5-triazines: Access to Chiral Tetrahydroquinazolines
Danqing Ji, Cheng Wang and Jiangtao Sun*
*Jiangsu Key Laboratory of Advanced Catalytic Materials &
Technology, School of Petrochemical Engineering, Changzhou University, Changzhou
213164, P. R. China, Email: jtsun
cczu.edu.cn
D. Ji, C. Wang, J. Sun, Org. Lett., 2018, 20, 3710-3713.
DOI: 10.1021/acs.orglett.8b01584
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Abstract
A copper-catalyzed asymmetric formal [4 + 2]-cycloaddition of copper-allenylidenes and hexahydro-1,3,5-triazines provides chiral tetrahydroquinazolines in good yields and with high enantioselectivities for most cases.
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Key Words
Tetrahydroquinazolines, benzo-fused N-heterocycles
ID: J54-Y2018
