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Regioselective Synthesis of Fluorosulfonyl 1,2,3-Triazoles from Bromovinylsulfonyl Fluoride

Joice Thomas and Valery V. Fokin*

*The Bridge@USC and Loker Hydrocarbon Research Institute, University of Southern California, Los Angeles, California 90089, United States, Email: fokinusc.edu

J. Thomas, V. V. Fokin, Org. Lett., 2018, 20, 3749-3752.

DOI: 10.1021/acs.orglett.8b01309 (free Supporting Information)


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Abstract

A general and regioselective metal-free cycloaddition of organic azides to a hitherto underexplored bromovinylsulfonyl fluoride building block provides 4-fluorosulfonyl 1,2,3-triazoles. This reaction was extended to the synthesis of various sulfonates, sulfonamides, and sulfonic acid derivatives of triazoles.

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Key Words

1,2,3-triazoles


ID: J54-Y2018