Regioselective Synthesis of Fluorosulfonyl 1,2,3-Triazoles from Bromovinylsulfonyl Fluoride
Joice Thomas and Valery V. Fokin*
*The Bridge@USC and Loker Hydrocarbon Research Institute, University of Southern California, Los Angeles, California 90089, United States, Email: fokinusc.edu
J. Thomas, V. V. Fokin, Org. Lett., 2018, 20, 3749-3752.
DOI: 10.1021/acs.orglett.8b01309 (free Supporting Information)
see article for more reactions
A general and regioselective metal-free cycloaddition of organic azides to a hitherto underexplored bromovinylsulfonyl fluoride building block provides 4-fluorosulfonyl 1,2,3-triazoles. This reaction was extended to the synthesis of various sulfonates, sulfonamides, and sulfonic acid derivatives of triazoles.
see article for more examples