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Iron-Catalyzed Nucleophilic Addition Reaction of Organic Carbanion Equivalents via Hydrazones

Chen-Chen Li , Xi-Jie Dai, Haining Wang, Dianhu Zhu, Jian Gao and Chao-Jun Li*

*Department of Chemistry and FRQNT Centre for Green Chemistry and Catalysis, McGill University, 801 Sherbrooke Street West, Montreal, Quebec H3A 0B8, Canada, Email: cj.limcgill.ca

C.-C. Li, X.-J. Dai, H. Wang, D. Zhu, J. Gao, C.-J. Li, Org. Lett., 2018, 20, 3801-3805.

DOI: 10.1021/acs.orglett.8b01391 (free Supporting Information)


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Abstract

Iron complexes are cheap and effective catalysts for a series of "umpolung" nucleophilic additions of hydrazones at room temperature. The catalytic system offers chemoselectivity and a broad substrate scope.

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Key Words

1,2-addition, benzylation


ID: J54-Y2018