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Direct Access to Versatile Electrophiles via Catalytic Oxidative Cyanation of Alkenes

De-Wei Gao, Ekaterina V. Vinogradova, Sri Krishna Nimmagadda, Jose M. Medina, Yiyang Xiao, Radu M. Suciu, Benjamin F. Cravatt and Keary M. Engle*

*Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States, Email: kearyscripps.edu

D.-W. Gao, E. V. Vinogradova, S. K. Nimmagadda, J. M. Medina, Y. Xiao, R. M. Suciu, B. F. Cravatt, K. M. Engle, J. Am. Chem. Soc., 2018, 140, 8069-8073.

DOI: 10.1021/jacs.8b03704 (free Supporting Information)


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Abstract

A catalytic, regioselective oxidative cyanation of conjugated and nonconjugated alkenes using a homogeneous copper catalyst and Selectfluor as oxidant provides branched alkenyl nitriles that are difficult to prepare.

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Key Words

vinyl nitriles, Selectfluor


ID: J48-Y2018