Direct Access to Versatile Electrophiles via Catalytic Oxidative Cyanation of Alkenes
De-Wei Gao, Ekaterina V. Vinogradova, Sri Krishna Nimmagadda, Jose M. Medina, Yiyang Xiao, Radu M. Suciu, Benjamin F. Cravatt and Keary M. Engle*
*Department of Chemistry, The Scripps Research Institute,
10550 North Torrey Pines Road, La Jolla, California 92037, United States, Email:
keary
scripps.edu
D.-W. Gao, E. V. Vinogradova, S. K. Nimmagadda, J. M. Medina, Y. Xiao, R. M. Suciu, B. F. Cravatt, K. M. Engle, J. Am. Chem. Soc., 2018, 140, 8069-8073.
DOI: 10.1021/jacs.8b03704
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Abstract
A catalytic, regioselective oxidative cyanation of conjugated and nonconjugated alkenes using a homogeneous copper catalyst and Selectfluor as oxidant provides branched alkenyl nitriles that are difficult to prepare.
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Key Words
ID: J48-Y2018
