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Regioselective Synthesis of γ-Lactones by Iron-Catalyzed Radical Annulation of Alkenes with α-Halocarboxylic Acids and Their Derivatives

Masayuki Iwasaki*, Natsumi Miki, Yuichi Ikemoto, Yasuyuki Ura and Yasushi Nishihara*

*Research Institute for Interdisciplinary Science, Okayama University, 3-1-1 Tsushimanaka, Kita-ku, Okayama 700-8530, Japan, Email:,

M. Iwasaki, N. Miki, Y. Ikemoto, Y. Ura, Y. Nishihara, Org. Lett., 2018, 20, 3848-3852.

DOI: 10.1021/acs.orglett.8b01436

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An abundant and low toxicity iron catalyst enables a regioselective annulation of alkenes with α-halocarboxylic acids and their derivatives in the absence of ligands, bases, and additives to afford various γ-lactones in good yields.

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Key Words


ID: J54-Y2018