N-Monomethylation of Aromatic Amines with Methanol via PNHP-Pincer Ru Catalysts
Osamu Ogata*, Hideki Nara, Mitsuhiko Fujiwhara, Kazuhiko Matsumura and Yoshihito Kayaki*
*Takasago International Corporation, 1-4-11 Nishi-Yawata, Hiratsuka, Kanagawa 254-0073; Tokyo Institute of Technology, 2-12-1-E4-1 O-okayama, Meguro-ku, Tokyo 152-8552, Japan, Email: osamu_ogatatakasago.com, ykayakio.cc.titech.ac.jp
O. Ogata, H. Nara, M. Fujiwhara, K. Matsumura, Y. Kayaki, Org. Lett., 2018, 20, 3866-3870.
DOI: 10.1021/acs.orglett.8b01449 (free Supporting Information)
Various aromatic amines were selectively methylated in the presence of MeOH and KOtBu into their corresponding monomethylated secondary amines in high yields at 150°C with very low loading of a PNHP-Pincer Ru catalyst.
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