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N-Monomethylation of Aromatic Amines with Methanol via PNHP-Pincer Ru Catalysts

Osamu Ogata*, Hideki Nara, Mitsuhiko Fujiwhara, Kazuhiko Matsumura and Yoshihito Kayaki*

*Takasago International Corporation, 1-4-11 Nishi-Yawata, Hiratsuka, Kanagawa 254-0073; Tokyo Institute of Technology, 2-12-1-E4-1 O-okayama, Meguro-ku, Tokyo 152-8552, Japan, Email: osamu_ogatatakasago.com, ykayakio.cc.titech.ac.jp

O. Ogata, H. Nara, M. Fujiwhara, K. Matsumura, Y. Kayaki, Org. Lett., 2018, 20, 3866-3870.

DOI: 10.1021/acs.orglett.8b01449 (free Supporting Information)


Abstract

Various aromatic amines were selectively methylated in the presence of MeOH and KOtBu into their corresponding monomethylated secondary amines in high yields at 150C with very low loading of a PNHP-Pincer Ru catalyst.

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Key Words

arylamines


ID: J54-Y2018