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2H-Chromene-3-carboxylic Acid Synthesis via Solvent-Controlled and Rhodium(III)-Catalyzed Redox-Neutral C-H Activation/[3 + 3] Annulation Cascade

Zhi Zhou, Mengyao Bian, Lixin Zhao, Hui Gao, Junjun Huang, Xiawen Liu, Xiyong Yu*, Xingwei Li and Wei Yi*

*School of Pharmaceutical Sciences & the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong 511436, China, Email: yiweigzhmu.edu.cn, yuxycnaliyun.com

Z. Zhou, M. Bian, L. Zhao, H. Gao, J. Huang, X. Liu, Y. Yu, X. Li, W. Yi, Org. Lett., 2018, 20, 3892-3896.

DOI: 10.1021/acs.orglett.8b01477 (free Supporting Information)



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Abstract

A solvent-controlled and rhodium(III)-catalyzed C-H activation/[3 + 3] annulation sequence enables an efficient and redox-neutral synthesis of 2H-chromene-3-carboxylic acids from N-phenoxyacetamides and methyleneoxetanones as a three-carbon source.

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Key Words

2H-chromenes


ID: J54-Y2018